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Although there is considerable research and development in biomaterials, there are only a handful of companies shipping commercial products. Fur thermore, the products are limited to replacement skin and cartilage. In the United States, the biotech giant Genzyme markets a process in which a patient s own cells are used to grow replacement skin or cartilage, which is then used to treat severe burns or damaged knees, respectively. It also of fers biomaterials that reduce the risk of adhesions following abdominal surgery. Another U.S. rm, Organogenesis, Inc., the rst rm to gain FDA approval for a mass-produced product containing living human cells, also offers skin and cartilage replacement technology. In Europe, IsoTis SA was formed in 2002 through the merger between Modex, a Swiss biotechnology company with a focus on skin management, and IsoTis, a Dutch biomedical company with a focus on orthopedics. Like Genzyme and Organogenesis, the company offers replacement skin and cartilage products that are cloned from the patient s own cells. Whether these and similar companies can survive in the long term depends on their

dx g(x)

(F.20)

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1. From the Vendors menu, choose Inventory Activities, and then choose Adjust Quantity/Value On Hand. The window shown in Figure 18-10 appears. 2. (Optional) Change the Adjustment date if appropriate, and enter a Ref. No. 3. Enter the name of the Adjustment account where you track inventory loss and shortages. 4. Change the Customer:Job and class, if needed. 5. For each inventory Item whose quantity has changed, enter either the new quantity or the quantity difference. 6. If you are disassembling an inventory assembly Item, select the assembly Item and each component Item in the list. (Assembly Items are listed alphabetically after all inventory parts in the Adjust Quantity/Value On Hand window.) Decrease the number of assembly units in inventory and increase the number of component Items to match. 7. (Optional) Click the Value Adjustment checkbox at the bottom and edit the value of the inventory. 8. Save the inventory adjustment.

is finite, we can obtain a delta function from it by taking the limit lim 'Y g(-yx)

ability to increase their portfolio of medically sound and economically vi able biomaterial products.

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Whenever I think of returned Items, I remember a story about a cousin who worked as a purchasing agent for a major hotel chain and ordered 1,000 pieces of silverware. The inventory code on an order form was misread, and 1,000 live chickens were delivered. It wasn t her fault, but she still had to deal with the squawking mess until they could be returned to the vendor. And someone somewhere had to make the proper adjustments to the inventory accounts. It may not be your fault when live animals arrive in place of utensils, but you still need to account for the returned goods. To record a return to a vendor after you ve already entered a bill, follow these steps: 1. Go to Vendors Enter Bills. 2. Select Credit at the top of the window. 3. Enter the vendor name. 4. Click the Items tab. 5. Enter the Items (that you either received, or are returning, or did not receive in the rst place). 6. Click Save & Close.

(F.21)

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QuickBooks offers a number of inventory reports, which you can access from the Reports Inventory menu as shown in Figure 18-11.

The promise of biomaterials is to address the need for replacement parts for the aging Western population and provide a cure for currently untreat able conditions. For example, as an increasing percentage of the popula tion in the United States and Europe succumb to the disabilities associated with old age, the demand for replacement parts will skyrocket. However, the current technologies available for hip replacement, for example, are based on titanium and other inert materials that eventually wear out. The typical titanium hip replacement must be replaced on average every ve years. Furthermore, patients frequently develop problems related to the in exibility and the particular dynamics of conventional implants. Eventually, biomaterial products will include biocompatible implants that provide extended drug delivery over months or years as they slowly dissolve. Arti cial blood substitutes will provide affordable, risk-free alter natives to traditional blood products, which are often contaminated with viruses. Ceramics under development will provide templates for new bone growth and regeneration, and meshes, foams, and gels under development will be used routinely to stimulate tissue growth. Moreover, many scien tists and clinicians foresee a future in which patients crippled by arthritis and other chronic diseases can regain the use of their hands, feet, and knees by replacing joints and bones with custom ceramic replacement bones and joints. Similarly, once nerve tissues can be regenerated or replaced in a con trolled manner, tissue repair will extend to retinas damaged by high blood pressure and diabetes, cochlear implants will recover lost hearing, and spinal cord replacements will correct spinal and other nerve damage from accidents and herniated discs.

(E22)

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