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more companies that have run afoul of the law. In 2003, the ad hoc advisory committee to the Federal Sentencing Commission concluded, after studying these compliance programs, that they failed to achieve effective compliance. In the wake of a seeming abundance of corporate scandals at the turn of the twenty- rst century, the U.S. Congress hastily wrote a new set of rules to govern corporate conduct, the Sarbanes-Oxley bill (commonly called SOX ), and revised the sentencing guidelines to react to those transgressions. Corporations again immediately allocated billions to gure out how to comply with the new regulations, just as they did a dozen years before.6 Consider this smaller example of the same phenomenon: A manager puts up a sign in your company lunchroom that says, Please Clean the Microwave after You Use It ; then another, Do Not Put Your Feet on the Tables ; then a third, Don t Eat Other People s Food. All these rules, and the myriad more little lunchroom dos and don ts that your manager madly prints out and posts, attempt to codify a single value, respect. Rather than declare a common value, such as Respect Our Common Spaces, most rules makers spend their time chasing human ingenuity, which races along generally complying with the rules while blithely creating new behaviors that exist outside of them. What does the persnickety lunchroom manager and his signs have in common with the U.S. government and Sarbanes-Oxley Both reveal a startling truth about rules: Rules respond to behavior; they don t lead it. Rules don t govern human progress; they govern the human past. This essential truth shapes our thinking about rules: To succeed, it seems to imply, we must learn to dance with the rules.

16.9 16.9.1

Reagents and Materials Sterile Freshly isolated primary rat hepatocytes (See Section 3) CHCM (See Section 2.6) HDHM (See Section 2.12) 70% Ethanol Collagen type I (rat tail), nal concentration approximately 500 g/ml Nonsterile Perfusion circuit (Fig. 15.9) including: medium reservoir, gas exchanger with gas permeable Silastic tubing, O2 probe (Clark-type electrode), syringe pump, bubble trap Flow deck: polycarbonate block containing inlet and outlet ports and 100- m recess over which slide can be placed Stainless steel bracket, screws Inert silicone lubricant 38 mm 75 mm glass microscope slides Incubator, PID controlled Protocol (a) Sterilize 38 mm 75 mm microscope slide with 70% ethanol and treat with type I collagen as described in Protocol 15.9. (b) Culture freshly isolated hepatocytes on slide to con uence with 2 seedings of 3 106 cells in Complete Hepatocyte Medium, followed by gentle horizontal shaking every 15 min for 1 h. (c) After additional 2-h incubation, change medium to HDHM. Proceed with the following steps on day 1 or 2 after isolation. The hormonally de ned preparation has been utilized in this procedure in order to help stabilize hepatocytes in monolayer culture, as previously described [Enat et al., 1984]. In addition, for the development of potentially clinical extracorporeal devices, it is important to optimize bioreactor parameters without the presence of nonhuman serum, which is incompatible with clinical approaches.

Executing the ShowWindowsDir procedure displays a message box with the Windows directory. Usually, Windows is installed in C:\WINDOWS, but that is not guaranteed. Windows NT is often installed in C:\WINNT, but not always. Often, you ll want to create a wrapper for API functions. In other words, you ll create your own function that uses the API function. This greatly simplifies using the API function. Here s an example of a wrapper VBA function:

approach to development, which suggested that development unfolds in a series of steps, xed and predetermined in order Only under extreme conditions, such as famine, war, or poverty, are children thrown off this biologically programmed timetable According to Gesell, the tendency to grow is the strongest force in life, and the inevitableness and surety of maturation are the most impressive characteristics of early development The inborn tendency toward optimum development is so inveterate that [the child] bene ts liberally from what is good in our practice, and suffers less than he logically should from our unenlightenment (Gesell, 1928, p 360) Gesell s years of careful observation produced a corpus of work that was not only a highly sophisticated account of motor development but an early version of a dynamic systems view of development (Thelen, 1993).

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on the reliability and validity of their opinions, and appropriately limit the nature and extent of their conclusions or recommendations. (See also Standards 2.01, Boundaries of Competence, and 9.06, Interpreting Assessment Results.) (c) When psychologists conduct a record review or provide consultation or supervision and an individual examination is not warranted or necessary for the opinion, psychologists explain this and the sources of information on which they based their conclusions and recommendations.

dietary behaviors to decrease caloric intake and consumption of fats, and to increase intake of dietary ber, (b) engaging in low-impact exercise such as walking, (c) using problemsolving skills to overcome barriers to adherence and consequently developing adaptive coping strategies, (d) establishing weekly personal goals, (e) increasing enjoyable social interaction, and (f) discussing strategies to prevent relapse Participants who received the immediate intervention condition showed signi cantly greater reductions in caloric and fat intake and weight as well as increases in the frequency of blood glucose monitoring as compared to the control group These results were maintained at the six-month follow-up and were quite similar to the delayed intervention group.